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Whats wrong with animal trials and in vitro studies? Harriet Hall, Aug 19 08 Amanda Peet Is My Hero Mark Crislip, Aug 14 08 Autism and Vaccines : Responding to Poling and Kirby Steven Novella, Jul 23 08 When Investigative Reporting Becomes Anti-Vaccine Propaganda David Gorski, Jul 14 08 Should We Study Chelation for Autism? British journalist Brian Deer investigates. It is difficult to make a scientific case without plausibility that is, what scientifically plausible explanation could be offered that would link a vaccine to ASD? However, it provided no evidence to link MMR to autism and the authors failed to produce any scientific references. 604-606 Summary: Madsen et al evaluated autism rates in Denmark from. I hope this kind of resource helps you refute arguments from patients, friends, and family members who might try to claim that we dont vaccinate because of the autism risk. Summary: A further study was published in the journal Pediatrics. 2008 Mar 31 Summary: This study set out to test the hypothesis that the increase in the rate of autism diagnoses is caused in part by diagnostic substitution meaning that in the past what is now diagnosed as autism. News Article, oct 18, 2016, by Jessica Firger, most experts today agree the belief that childhood vaccines cause autism is based on bunk science. David Gorski, Feb 25 13, one Flu Into the Cuckoos Nest. This finding has implications for our understanding of the epidemiology of autism.
MMR and autism: further evidence against a causal association. Thanks for the Measles David Gorski, Aug 24 08 Peruvian Hamsters and Autism: Cui Bono? The aim of this study was to assess whether there was an association between MMR vaccination and encephalitis, aseptic meningitis, and autism. Comprehensive analysis of the reported adverse reactions established that serious events causally related to MMR vaccine are rare and greatly outweighed by the risks of natural MMR diseases. The methods indicate: Population-based cohort study of all children born in Denmark from January 1, 1990, until December 31, 1996 (N 467,450) comparing children vaccinated with a thimerosal-containing vaccine with children vaccinated with a thimerosal-free formulation of the same vaccine. Summary: Research letter published in The Lancet on 28th March 1998, written by Eric Fombonne that suggests no particular association between Crohns disease and autism among children immunised with MMR. This study does not support the theory that MMR causes immunological overload in children. Therefore there isnt really an autism epidemic just a change in the definition and efforts to make the diagnosis. In my article, Vaccines and autism science says they are unrelated, I list out over 125 published, peer-reviewed articles (as of today) that basically provide us with some of the overwhelming evidence that debunks the myth that vaccines cause autism. Jay Gordon: Full of sound and fury, signifying nothing Joseph Albietz, Apr 30 10 The Vaccine War David Gorski, Apr 29 10 The Other Anti-Vaccinationists Steven Novella, Apr 28 10 Social Factors in Autism Diagnosis Steven Novella, Apr 14 10 Steven Higgs: Another antivaccine reporter like Dan Olmsted in the making?
Recall bias, MMR and autism. This is consistent with other studies and is essentially what we expect if thimerosal does not cause neurodevelopmental disorders. This is the expected statistical noise, occurring by chance alone. Study of thimerosal and measles, mumps and rubella (MMR) vaccine uptake in 28,000 Canadian children born between 19, of whom 180 were identified with a pervasive developmental disorder. What were you expecting? Time trends in autism and in MMR immunization coverage in California. These findings indicate no harmful association between MMR vaccine receipt and ASD even among children already at higher risk for ASD.
And the results: Only in 1 analysis for tics was there some evidence of a higher risk with increasing doses. The researchers conclude: We could find no convincing evidence that early exposure to thimerosal had any deleterious effect on neurologic or psychological outcome. findings of this meta-analysis suggest that vaccinations are not associated with the development of autism or autism spectrum disorder. 2014 Jun 17;32(29 3623-9. They found: Among the 42 neuropsychological outcomes, we detected only a few significant associations with exposure to mercury from thimerosal. (A more detailed analysis of this article can be found here. Hornig M, Briese T, Buie T, Bauman ML, Lauwers G,. Summary: Used the GP Research Database to compare MMR vaccine coverage over time with reported rates of autism.
The Pediatric Infectious Disease Journal: 1 December 2009. Chen W, Landau S, Sham P, Fombonne. The researchers determined the risk of ASD in mothers who either were vaccinated against or who contracted the flu. Summary: From the abstract: Studies do not demonstrate a link between thimerosal-containing vaccines and ASD, and the pharmacokinetics of ethylmercury make such an association less likely. This retrospective, cohort study of 95,7272 children examined the risk of autism spectrum disorder (ASD) between groups who had been vaccinated with the MMR vaccine and those who had not. Epub 2010 May. The authors argue that these movement disorders are a reliable indicator of autism before the diagnosis is typically recognized research papers/childhood vaccines linked to autism by parents and formally diagnosed. The vaccination histories for 189 children with ASD was compared to the histories of 224 controls to determine the relationship between MMR vaccination and ASD. Summary: The US Institute of Medicine Immunisation Safety Review Committee published a report which concluded: The evidence favours rejection of a causal relationship at the population level between MMR vaccine and autistic spectrum disorders (ASD). The Incidence of Autism in Olmsted County, Minnesota. Epub 2013 Mar. Afzal MA, Ozoemena LC, OHare A, Kidger KA, Bentley ML,. Relation of childhood gastrointestinal disorders to autism: nested case-control study using data from the UK General Practice Research Database.
They further argue that these indicators are likely present from birth. Vaccine may not be a cause of autism Mumper Can Awareness of Medical Pathophysiology in Autism Lead to Primary Care Autism Prevention Strategies? The authors state that Given the research papers/childhood vaccines linked to autism real risks of not vaccinating and that the risks and existence of variant ASD remain theoretical, current policies should continue to advocate the use of MMR vaccine. (For a more detailed history and analysis see Brian Deers investigation.) Afzal M A,. A total of 12 studies (from 5 countries) examining the hypotheses put forward by Dr Wakefield and colleagues were reviewed in detail. Madsen KM, Lauritsen MB, Pedersen CB, Thorsen P, Plesner AM, Andersen PH, Mortensen. Another 752 children without autism, matched to the ASD children by birth year, gender and managed care organization, were also studied. No neuronal cellular or protein changes in the cerebellum, hippocampus, or amygdala were observed in animals following the 1990s or 2008 vaccine schedules. Halsey.,. The first phase looked at 124,170 children from from two HMOs and found an association between thimerosal exposure and tics in the first HMO and an association between thimerosal and language delay (but not tics) at the second HMO. They are simply among the weakest type of study you can. David Gorski, Apr 1 13, blame and magical thinking: The consequences of the autism biomed movement. Absence of detectable measles virus genome sequence in blood of autistic children who have had their MMR vaccination during the routine childhood immunization schedule.
Paper refuting links between vaccination of pregnant mother and autism Citation Summary Authors conclusion Zerbo O, Qian Y, Yoshida C, Fireman BH, Klein NP, Croen. There wasno dose response relationship between autism symptoms and antibodylevels. Its important that the report by Wakefield of several children whose chronic bowel and behavioral abnormalities were linked by their parents and physicians to measles, mumps, and rubella (MMR) vaccination are examined, critically and with an open mind. Journal of Child Psychology and Psychiatry 46(6 57279. However, this study does not reflect any increased risk of autism in those receiving either type of vaccine. Some in the anti-vaccine camp have cherry-picked the weak association with tics, but there is no more reason to think that correlation is anything other than random noise than there is to believe that thimerosal protects against adhd based upon this data. Journal of the American Medical Association 2003;290:1763-1766. DeStefano F, Thompson. Jay Gordon and me: Random encounters with an apologist for the antivaccine movement David Gorski, Oct 20 08 When Compassion Outshines Ignorance Peter Lipson, Oct 20 08 Autisms False Prophets Revealed David Gorski, Sep 29 08 Sometime Ethics and Science Win Out David Gorski. Children published at Open Access Text (is that really a journal?) after it was retracted at another journal last year, this survey of homeschoolers is being billed as the First Peer-Reviewed Study of Vaccinated versus research papers/childhood vaccines linked to autism Unvaccinated Children. Farrington.,. What about any new studies they say supports a link between vaccines and autism?
During the period of measles, mumps and rubella vaccine (MMR) usage, no significant difference was found in the incidence of regression between MMR-vaccinated children and non-vaccinated children. Ask the Editor Journal of Autism and Developmental Disorders (August 1999) Vol 29:No 4:1999 Summary: Letter in the Journal of Autism and Developmental Disorders that examines whether measles infections or measles immunisations are linked to autism. Summary: This study concluded that causality between immunisation and a subsequent untoward event cannot be estimated solely on the basis of a temporal relation. Further, the best epidemiological evidence suggests that the rise in the diagnosis rate of ASD is an artifact of broadening the definition of autism, diagnostic substitution, and increased surveillance. This study therefore lends strong support to a lack of association between thimerosal exposure from vaccines and neurodevelopmental disorders. Mark Crislip, Dec 17 10 Be thankful: No anti-vaccine propaganda at the movies this weekend David Gorski, Nov 25 10 Improving Our Response to Anti-Vaccine Sentiment Scott Gavura, Nov 6 10 Homeopathic Vaccines. Patja A,.
Researchers also checked hospital and health center records or interviewed the local public-health nurses. It examined the possibility of links between vaccination and autism, MMR vaccine and autism, and thimerosal and autism. There is no scientific evidence to support this hypothesis. Summary: The aim of this study was to estimate the prevalence of autism and to look at whether parental perception regarding the onset or causes of autism had changed over that time. They found no difference in autism rates between the two groups. At that time also the routine vaccine schedule was increasing, resulting in an increasing total dose of thimerosal. Do children who become autistic consult more often after MMR vaccination? On the contrary, all results from vaccine trials published reaffirm the high safety of MMR vaccine. This paper highlights that there is a significant degree of recall bias in parents of autistic children with regressive features who were diagnosed after the publicity alleging a link between MMR and autism. Early exposure to the combined measles-mumps-rubella vaccine and thimerosal-containing vaccines and risk of autism spectrum disorder. They concluded that using the best available polymerase chain reaction ( PCR ) technology, they were unable to find measles virus genome in gut mucosal biopsies from patients with Crohns disease or ulcerative colitis. They often spread misinformation about vaccine, such as the notion that vaccines weaken the immune system, when in fact they work by strengthening the immune response against the target infection.
David Gorski, Dec 28 11 What Is an Antivaxer? The cause(s) of autism remains unclear. Effect of Pentavac and measles-mumps-rubella (MMR) vaccination on the intestine. Journal of Medical Virology 2000; 62: 377-82. Mawson Pilot comparative study on the health of vaccinated and unvaccinated research papers/childhood vaccines linked to autism 6- to 12- year old.S.
Journal of American Medical Association 2003;289 (1 49-55. 2003 Oct 1;290(13 1763-6. Continuing increases in autism reported to Californias developmental services system: mercury in retrograde. Research Papers Supporting the Vaccine/Autism Link. This and other evidence supports the conclusion that there is no true autism epidemic, just a change in diagnostic practices. The less-vaccinated children did not do significantly better on any of the outcomes Timely vaccination during infancy has no adverse effect on neuropsychological outcomes 7 to 10 years later. They found so significant difference in the risk of being Rh- or having been exposed to thimerosal in mothers with ASD children compared to the general population.
Undaunted, the antivaccinationists have changed their claims to blame any number of toxins in vaccines. Absence of plausibility Ive made this point before. 2005;66 Suppl 10:ick here to read Jick H, Kaye. Autism and measles, mumps, and rubella vaccine: no epidemiological evidence for a causal association. Farrington CP, Miller E, Taylor. David Gorski, Sep 13 10 A pox on your bank account: failure to vaccinate and its legal consequences Jann Bellamy, Aug 27 10 How to make a difference Responsible vaccine advocacy Joseph Albietz, Aug 20 10 Pertussis Epidemic 2010 Steven Novella, Aug 18 10 Terrible Anti-Vaccine Study, Terrible Reporting. Afzal A,. Share, comment 75 Comments, view our comment policy. I think its more important to focus on the handful of the best studies that provide the best evidence. The results provided further evidence against a causal association between the MMR vaccine and autism. 2014 Mar 27;370(13 1209-19. Therefore, these findings indicate that there is no basis for avoiding vaccination out of concern for ASD.